CLINICAL TRIALS AND OBSERVATIONS A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload
نویسندگان
چکیده
1Children’s Hospital, Harvard University, Boston, MA; 2Università degli Studi di Cagliari, Cagliari, Italy; 3Siriraj Hospital, Mahidol University, Bangkok, Thailand; 4Pediatric Haematology, Ege University Hospital, Izmir, Turkey; 5Scienze Cliniche e Biologiche, Torino, Italy; 6Gastroenterology, Children’s Hospital & Research Center Oakland, Oakland, CA; 7Centro della Microcitemia e delle Anemia Congenite-Ematologia, Ospedale Galliera, Genoa, Italy; 8Haematology, The Whittington Hospital, London, United Kingdom; 9University College London, London, United Kingdom; 10Cardiology, Children’s Hospital Los Angeles, Los Angeles, CA; and 11FerroKin BioSciences Inc, San Carlos, CA
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS Effect of transfusional iron intake on response to chelation therapy in -thalassemia major
The success of chelation therapy in controlling iron overload in patients with thalassemia major is highly variable and may partly depend on the rate of transfusional iron loading. Using data from the 1-year phase III study of deferasirox, including volumes of transfused red blood cells and changes in liver iron concentration (LIC) in 541 patients, the effect of iron loading on achieving neutra...
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The role of iron overload as cause of liver dysfunction has never been studied in detail in patients without concomitant hepatotropic infections who receive multiple transfusions. We therefore investigated the relationship between the extent of hepatocellular injury as reflected by serum levels of aminotransferases (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) and severa...
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The importance of iron and copper in cancer biology has been well established. Iron plays a fundamental role in cellular proliferation and copper has been shown to be a significant cofactor for angiogenesis. Early observations with the chelator used for the treatment of iron overload, desferrioxamine, showed that it had promise as an anticancer agent. These results sparked great interest in the...
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Use of the iron chelator deferiprone for treatment of iron overload in thalassemia patients is associated with concerns over agranulocytosis, which requires weekly absolute neutrophil counts (ANC). Here, we analyze all episodes of agranulocytosis (n = 161) and neutropenia (n = 250) during deferiprone use in clinical trials (CT) and postmarketing surveillance programs (PMSP). Rates of agranulocy...
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